Tag: Registerbased research

Risk for suicide attempt in the offspring of parents with suicide attempt.

In this study we use data from Danish, nationwide registers to investigate risk of suicide attempt in individuals whose parents have attempted suicide. Results show that parental suicide attempt is associated with a 3-fold increased risk of suicide attempt in the offspring. Risks are highest if the parent attempted suicide during early childhood of the offspring. Risks were slightly higher for children of mothers than fathers with suicide attempt. Suicide attempt in a stepparent was associated with a 1,7 fold risk of suicide attempt in the stepchild. Analyses are adjusted for important socioeconomic confounders.

DRISP: Anne Ranning, Annette Erlangsen, Trine Madsen, Merete Nordentoft

Partners:

  • Center for Register-based Research

iCare: Psychoeducation for parents of children

Approximately, 11,000 self-harm episodes occur on a yearly basis in Denmark. Of these, the majority are among youth below the age of 25 years. The Suicide Prevention Clinics experience that parents often request information on how they can best help their child after a self-harm episode. The aim of this project is to 1) in collaboration with parents to develop a webpage for this group, 2) to test whether the webpage can help reduce the stress burden that parents experience in a randomised trial, 3) to examine whether parents of children who self-harm have a higher rate of stress-related response when compared to parents not exposed. The project has received 3.7 DKR from the Danish TRYG Foundation

DRISP: Jette Louise Skovgaard Larsen, Anette Juel Kynde, Britt Morthorst, Annette Erlangsen


Partners

  • Elene Fleischer, PhD Netværk for selvmordsramte (www.nefos.dk)
  • Niels Buus, Mental Health Nursing, Sydney Nursing School, University of Sydney
  • Jan-Henrik Winsløw, Enhed for Selvmordsforebyggelse, Region Nordjylland
  • Prof Keith Hawton, Centre for Suicide Research, University of Oxford

Suicide risk associated with psychiatric hospitalization

To examine the trend and excess risk of suicide in suicidal high-risk phases, namely among psychiatric inpatients and recently discharged patients. We will examine the risk in these high-risk phases according to sex, age-groups and psychiatric diagnoses.


DRISP: Trine Madsen, Merete Nordentoft & Annette Erlangsen

Suicide risk according to highest level of psychiatric service received

Different patient groups are seen across psychiatric sectors and it is relevant to know which groups are at imminent risk of suicide. In this project, the risk of suicide is examined according to the highest level of psychiatric service received. The level will be graded according to severity as well as by type of contact, such as psychiatric admission, psychiatric ER visit, psychiatric outpatient, psychiatric medicine.

DRISP: Trine Madsen, Merete Nordentoft, Annette Erlangsen

Lyme disease and risk of suicidal behaviour suicidal adfærd

We will examine the risk of suicidal behavior associated with Lyme disease. We will look into how this risk is according to age of infection with Lyme, number of infections, days hospitalized due to Lyme disease and time since Lyme disease.


DRISP: Trine Madsen, Merete Nordentoft & Annette Erlangsen

Partners:

  • Michael Eriksen Benros, Research Unit, Mental Health Centre Copenhagen
  • Brian A. Fallon, MD, Center for Neuroinflammatory Disorders and Biobehavioral Medicine and director of the Lyme and Tick-Borne Diseases Research Center at Columbia University, USA

Combat exposure and risk of suicide attempt in previously deployed soldiers

In this study we have information on 13.000 deployed soldiers who reported on combat exposure after home-coming in a survey and this is linked to register-based data on self-harm/suicidal attempt.

Partners:

Traumatic brain injury (TBI) and risk of suicidal behaviour

We found that the risk of suicide is almost twice as high in people who experienced a TBI compared with people who had no TBI records. The risk was especially high in the first period after the TBI incident and oncreased by number of experienced TBI’s.

Internationale media
Washington Post
Reuters
ABC News
The Telegraph (britiskmedie)


The study has been published in JAMA.

DRISP: Trine Madsen, Merete Nordentoft & Annette Erlangsen

Partners:

  • Michael Eriksen Benros Research Unit, Mental Health Centre Copenhagen

Suicide rates in Nordic prisons 1999-2016

International research has shown an increased suicide rate among people in prison.  However, studies have yet to address age structural differences. In this longitudinal the suicide rates among male prisoners is compared to the general population in three Nordic countries, Denmark, Iceland, and Norway,  while adjusting for age differences.

Findings from the study shows that men in prison have a 7-fold higher suicide rate compared to the background population in Denmark, Iceland, and Norway and when accounting for age differences. For females, a rate 18-fold higher suicide rate was found among those in prison when compared to the general population. Over the 17-year study period, the suicide rate of people in prison decreased from 129 per 100,000 in 1999 to 70 per 100,000 in 2016. This decline was steeper that the decline observed for the suicide rate in the general population in the Nordic countries.

Link to study

https://www.tandfonline.com/doi/abs/10.1080/13811118.2020.1746943


DRISP: Britt Morthorst, Charlotte Mühlmann, Trine Madsen, Merete Nordentoft
og Annette Erlangsen

Partners

  • Lars Mehlum, Professor, National Centre for Suicide Research and Prevention, Institute of Clinical Medicine Oslo, Norway
  • Aiguröur Pàlsson, MD, Unit of Forensic Psychiatry, Iceland
  • Högni Óskarsson, md, Humus inc., Iceland Yngve Hammerlin, MD, Correctional Service of Norway Staff Academy, Norway

Call volume to a national suicide hotline, the Lifeline

It is estimated that between 50-60% of callers to suicide hotlines might be in an acute crisis and as many as 56% have reported to have had a previous suicide attempt. It is, thus, important to answer these calls. In Denmark, the Lifeline answers >14,000 calls on a yearly basis but many calls remain unanswered. The aim of this research project is to examine how many calls to the Lifeline are answered as well as to determine peak call hours during the day.

The project has received support from the Partnership for Suicide Prevention, Danish Health Authority

DRISP: Annette Erlangsen

Partners:

  • Livslinien

Bereaved by suicide: psychological mechanism

To lose a next of kin to suicide can be an extremely distressing event. Studies show that bereaved by suicide have an elevated risk of stress-related diseases and suicidal behaviour themselves. The aim of this study is to examine the psychological mechanisms that affect the risk of suicidal behaviour among bereaved by suicide. These insights are needed in order to optimise the support for bereaved by suicide.
The project has received support from the American Foundation for Suicide Prevention

DRISP: Annette Erlangsen

Partner:

  • Dr Alexandra Pitman, Senior Clinical Lecturer, UCL Division of Psychiatry (projektansvarlig)
  • Dr Gemma Lewis, Research Associate in Psychiatric Epidemiology, UCL Division of Psychiatry
  • Professor Julie Cerel, Professor, College of Social Work, University of Kentucky


Bereaved by suicide and affected by suicide: how many receive help?

Every year about 600 suicide deaths and 11,000 suicide attempts are recorded in Denmark. Next to each suicidal act are numerous relatives and other next of kin who are deeply affected. Specialised support for bereaved and affected is being provided by volunteer organisations and it is unclear how many receive help. This research project will seek to map how many bereaved by suicide and affected by suicidal behaviour receive support from Nefos, one of the Danish volunteer organisations.


The project has received support from the Partnership for Suicide Prevention, Danish Health Authority

DRISP:  Annette Erlangsen


Partner:

  • Elene Fleischer, PhD Netværk for selvmordsramte (NEFOS)

Neurological disorders and suicide

Neurological disorders have severe impacts on people’s lives in terms of both disability and dependency and have been linked to suicide. Yet, a comprehensive overview was lacking. This study examined whether people with specific neurological disorders die by suicide more often than other people. The study was based on the register data covering the entire population of Denmark during 1980-2016.

The findings from study, which was published in JAMA, shows that people with neurological disorders have a 75% higher suicide rate than people with no neurological disorders. Still, suicide deaths are rare events. While the suicide rate for the general population was around 20 per 100,000, the rate for people with neurological disorders is around 40 per 100,000 person-years. One out of 150 persons diagnosed with a neurological disorder dies by suicide. For severe neurological diseases, such as Huntington’s, one out of 61 diagnosed went on to die by suicide. This study is the most comprehensive assessment of neurological disorders’ link to suicide conducted to date.

The study shows that people who have been diagnosed with amyotrophic lateral sclerosis (ALS) or Huntington’s disease have a particular high risks, as the suicide rate associated with these disorders is 4-5 times higher than in the general population. People who have been exposed to traumatic brain injury, multiple sclerosis, or epilepsy have a suicide rate, which is double the level of the one found among those with no such disorders.

People with dementia were found to have a 2-3 time higher suicide rate during the first three months after being diagnosed. On the other hand, people who had been diagnosed with dementia more than a year ago were found to have a lower suicide rate than the general population.

– This is the first time we have examined this many different neurological disorders to gain a more detailed understanding of when risk of suicide is pronounced. These insights can help us shape dedicated preventive effort says Dr. Annette Erlangsen, lead author and senior researcher at Danish Research Institute for Suicide Prevention (DRISP). The project has received support from the Psychiatric Research Foundation, Region of Southern Denmark.

Link to study:

https://jamanetwork.com/journals/jama/article-abstract/2760389



DRISP: Annette Erlangsen, Merete Nordentoft

Partners:

  • Egon Stenager, Department of Neurology, Sønderborg, Hospital of Southern Jutland, Denmark
  • Yeates Conwell, Center for the Study and Prevention of Suicide, University of Rochester Medical Center, USA
  • Per Krag Andersen, Section of Biostatistics, University of Copenhagen, Denmark
  • Keith Hawton, Centre for Suicide Research, University of Oxford, United Kingdom
  • Michael Eriksen Benros, Research Unit, Mental Health Centre Copenhagen, Copenhagen, Denmark
  • Elsebeth Stenager, Department of Regional Health Research, University of Southern Denmark, Odense, Denmark

Paracetamol-project (Danish Pack size restriction)

Paracetamol is reported to be the most frequently used drug for overdoses in European countries. An international concern has emerged and interventions, such as age and pack size restriction on non-opioid analgesics sold OTC in pharmacies, have been implemented.
The method applied was a nationwide register study investigating the trend in hospital admissions for non-opioid analgesic poisonings before and after the implementation of age and pack size restriction in Denmark in 2011 and 2013, respectively. The trend in rates of severe poisonings was also investigated using nationwide laboratory data as blood tests taken routinely during admission in the period 2011-2013. After the age and the pack size restriction we found significantly reduced numbers of non-opioid analgesics poisonings. Also, the number of severe poisonings treated in Danish hospitals decreased after the pack size restriction indicating reduced risk of liver injury.
We concluded that a significant reduction in trends of poisoning by non-opioid analgesics treated in hospitals and fewer severe poisonings was observed after the legislative changes in Denmark.

Link to the study: https://www.sciencedirect.com/science/article/pii/S016503271932957X

The project in the media
Politiken

DRISP: Britt Morthorst

Partners:

  • Frank Eriksson, PhD, Associate Professor, Institute of Biostatistics, University of Copenhagen
  • Keith Hawton, Centre for Suicide Research, University of Oxford, United Kingdom


Workplace bullying and suicidal behaviour

Although workplace bullying is considered a stressful life-event, there is scarce evidence about its’ role as a risk factor for suicide attempt and death by suicide. The aim of this project is to examine whether people who report to have been exposed to workplace bullying have higher rates of suicidal behaviour than those not exposed.

The project has received support from the Psychiatric Research Foundation, Region Southern Denmark

DRISP: Annette Erlangsen

Partners:

  • Paul Maurice Conway, Institut for Psykologi, Københavns Universitet
  • Thomas Clausen, Det Nationale Forskningscenter for Arbejdsmiljø, København
  • Annie Høgh, Institut for Psykologi, Københavns Universitet
  • Elsebeth Stenager, Department of Regional Health Research, University of Southern

Suicidal behaviour after among victims of physical or sexual abuse

Abuse of children and youth is an important problem to emphasize and prevent. This project conducts a large, representative, study of victims of sexual and physical abuse.
The project has received support from the Danish Health Care Foundation.

DRISP: Annette Erlangsen & Merete Nordentoft

Partners

  • Holly Wilcox, Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, USA
  • Prof Elizabeth J. Letourneau, Moore Center for the Prevention of Child Sexual Abuse Johns Hopkins Bloomberg School of Public Health
  • Kairi Kolves, Australian Institute for Suicide Research and Prevention, WHO Collaborating Centre in for Research and Training in Suicide Prevention at Griffith University